Aspartame – Poison

 

Aspartame breaks down into the body by ester hydrolysis causing the production of a methoxide anion. MeO-  The basicity of which (its conjugate acid, methanol, has a pKa of about 15) to far too great to allow it to exist in that form in the body. An acid/base reaction occurs in which it bocomes protonated forming methanol (which already destroys proteins). The methanol itself then gets oxidised in the body into methanal (formaldehyde – which is also very toxic to body tissues – formaldehyde is the fluid used to preserve biological tissues in ones body). All of this is standard chemistry and biochemistry. Nothing conspiratorial about it at all and is just two (methanol / methanal) reasons not to use aspartame or food products.

The conspiracy begins here:

Food products are sometimes say on their labeles “contains a source of phenylalanine“. They say that becasue they know people don’t want to consume aspartame as people are increasingly aware of its adverse effects – a gradual slow posioning which ramps up according to quantity ingested leading to a number of debililitating conditions. They should of course say “contains the poison aspartame” but honesty and health safety comes lower on the scale of priorities of those who make millions from its sale and incorporation into food products. 

Please read about aspartame. It really is a posion. Below is just one documentary on it called: “Sweet Misery – Poisoned World” available from the superb website http://nw0.info

http://nw0.info/files/Documentaries/Aspertame%20-%20Sweet%20Misery%20-%20A%20Poisoned%20World/Aspertame%20-%20Sweet%20Misery%20-%20A%20Poisoned%20World.avi

(or if you prefer short URL’s : http://tinyurl.com/3xnxef)

695.1 Mb (avi format) – a download manager might prove useful here.

For what it’s worth, please petition your MP to stop the inclusion of asparatme in food products. Some MP’s have already expressed concern about it. {6,000 products contain aspartame}

Safety of artificial sweetener called into question by MP

(Roger Williams  MP) 

http://www.guardian.co.uk/politics/2005/dec/15/foodanddrink.immigrationpolicy

UPDATE: Headlined on 3/22/08:
Aspartame and Rumsfeld’s Disease- A Politically-Induced Biochemical Disaster of Global Proportions at http://www.opednews.com/articles/opedne_don_hark_080321_aspartame_and_rumsfe.htm 

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18 Responses to “Aspartame – Poison”


  1. 1 rightnote March 12, 2008 at 4:16 pm

    Please do check out the aspartame study done by a private citizen.

    http://myaspartameexperiment.com

    Thanks.

  2. 2 Rich Murray March 13, 2008 at 2:17 am

    methanol impurity in alcohol drinks [ and aspartame ] is turned into neurotoxic formic acid, prevented by folic acid, re Fetal Alcohol Syndrome, BM Kapur, DC Lehotay, PL Carlen at U. Toronto, Alc Clin Exp Res 2007 Dec. plain text: detailed biochemistry, CL Nie et al. 2007.07.18: Rich Murray 2008.02.24

    http://rmforall.blogspot.com/2008_02_01_archive.htm
    Sunday, February 24, 2008
    http://groups.yahoo.com/group/aspartameNM/message/1524
    ____________________________________________________

    [ Rich Murray comments: As a medical layman volunteer information
    activist for aspartame and related toxicity issues since January 1999, I note with appreciation the remarkable exponential progress on all fronts, including a rapidly emerging consensus about the primary
    importance of all toxicity challenges for our world.

    This lengthy review features in detail two quite different, revolutionary contributions, from Canada, and England and China.

    It is indicative of our times that the CL Nie et al. study, 2007
    appears in a free, open access journal -- indeed,
    as all life and death information must.

    Following rather vigorously, indeed blindly, the imperatives of
    single-minded, profit-driven capitalist competition -- manipulating
    adroitly research, education, media, citizens, governments -- many
    great global corporations have inevitably created results that
    oppose the common good. Alcohol and tobacco are well known.

    Realistically, any further manipulations can only lead to inevitable
    and even sudden corporate meltdowns, in the context of an
    unfettered, cooperative, democratic global information forum,
    the Internet.

    Now, it is as easy and cheap to compose and instantly post a
    30-page review as 3 pages a decade ago -- and such reviews
    are archived forever in multiple collections, open via global search
    engines to a billion Net citizens.

    Perforce, and increasingly happily, all societal entities will have to operate by high and shared voluntary universal standards
    for the common good. ]

    http://www.blackwell-synergy.com/doi/abs/10.1111/j.1530-0277.2007.00541.x

    Alcoholism: Clinical and Experimental Research
    Volume 31 Issue 12 Page 2114-2120, December 2007

    Bhushan M. Kapur, b.kapur@utoronto.ca;
    Arthur C. Vandenbroucke, PhD, FCACB
    Yana Adamchik,
    Denis C. Lehotay, dlehotay@health.gov.sk.ca;
    Peter L. Carlen carlen@uhnres.utoronto.ca;
    (2007) Formic Acid, a Novel Metabolite of Chronic Ethanol
    Abuse, Causes Neurotoxicity, Which Is Prevented by Folic Acid
    Alcoholism: Clinical and Experimental Research 31 (12), 2114-2120.
    doi:10.1111/j.1530-0277.2007.00541.x

    Abstract

    Background:
    Methanol is endogenously formed in the brain and is present as a
    congener in most alcoholic beverages.

    Because ethanol is preferentially metabolized over methanol (MeOH)
    by alcohol dehydrogenase, it is not surprising that MeOH
    accumulates in the alcohol-abusing population.

    This suggests that the alcohol-drinking population will have higher
    levels of MeOH’s neurotoxic metabolite, formic acid (FA).

    FA elimination is mediated by folic acid.

    Neurotoxicity is a common result of chronic alcoholism.

    This study shows for the first time that FA,
    found in chronic alcoholics, is neurotoxic
    and this toxicity can be mitigated by folic acid administration.

    Objective:
    To determine if FA levels are higher in the alcohol-drinking
    population and to assess its neurotoxicity in organotypic
    hippocampal rat brain slice cultures.

    Methods:
    Serum and CSF FA was measured in samples from both ethanol
    abusing and control patients, who presented to a hospital emergency
    department. [ CSF = Cerebral Spinal Fluid ]

    FA’s neurotoxicity and its reversibility by folic acid were assessed
    using organotypic rat brain hippocampal slice cultures using clinically
    relevant concentrations.

    Results:
    Serum FA levels in the alcoholics
    (mean ± SE: 0.416 +- 0.093 mmol/l, n = 23)
    were significantly higher than in controls
    (mean ± SE: 0.154 +- 0.009 mmol/l, n = 82) (p 0.15 mmol/l in CSF of 3 of the 4 alcoholic cases.

    Low doses of FA from 1 to 5 mmol/l added for 24, 48 or 72 hours
    to the rat brain slice cultures caused neuronal death as measured by
    propidium iodide staining.

    When folic acid (1 umol/l) was added with the FA,
    neuronal death was prevented. [ umol = micromole ]

    Conclusions:
    Formic acid may be a significant factor in the neurotoxicity of
    ethanol abuse.

    This neurotoxicity can be mitigated by folic acid administration
    at a clinically relevant dose.

    Key Words:
    Formic Acid, Folic Acid, Methanol, Neurotoxicity, Alcoholism.

    From the Department of Clinical Pathology (BMK),
    Sunnybrook Health Science Centre,
    Division of Clinical Pharmacology and Toxicology,
    The Hospital for Sick Children, Toronto, Ontario, Canada;

    St. Michael’s Hospital (ACV), Toronto, Canada;

    Department of Laboratory Medicine and Pathobiology
    (BMK, ACV), Faculty of Medicine,
    University of Toronto, Toronto, Ontario, Canada;

    Departments of
    Medicine (Neurology) and Physiology (YA, PLC),
    Toronto Western Research Institute,
    University of Toronto, Toronto, Ontario, Canada;

    and University of Saskatchewan (DLC), Saskatchewan, Canada.

    Received for publication May 1, 2007;
    accepted September 24, 2007.

    Reprint requests: Dr. Bhushan M. Kapur,
    Department of Clinical Pathology,
    Sunnybrook Health Science Centre,
    2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada;
    Fax: 416-813-7562; E-mail: b.kapur@utoronto.ca;

    Copyright 2007 by the Research Society on Alcoholism.
    DOI: 10.1111/j.1530-0277.2007.00541.x
    Alcoholism: Clinical and Experimental Research 2007 Dec.
    Alcohol Clin Exp Res, Vol. 31, No 12, 2007: pp 2114-2120

    NEUROTOXICITY AND BRAIN damage are common
    concomitants findings of chronic alcoholism
    (Carlen and Wilkinson, 1987; Carlen et al., 1981; Harper,
    2007).

    The cause of ethanol-induced neurotoxicity is still unclear.

    We present here a novel hypothesis for neurotoxicity:
    increased formic acid (FA) levels produced from methanol
    (MeOH), whose catabolism is blocked by ethanol.

    Axelrod and Daly (1965) demonstrated the endogenous formation
    of MeOH from S-adenosylmethionine (SAM) in the pituitary
    glands of humans and various other mammalian species.

    Presence of MeOH in the breath of human subjects was
    reported by Ericksen and Kulkarni (1963).

    Most alcoholic beverages also have a small amount of MeOH
    as a congener (Sprung et al., 1988).

    As ethanol (EtOH) has a higher affinity for
    alcohol dehydrogenase (ADH) than MeOH,
    EtOH is preferentially metabolized (Mani et al., 1970).

    As a result, MeOH accumulation from endogenously produced
    MeOH, and/or, that consumed as part of an alcoholic beverage,
    has been reported in concentrations up to 2 mmol/l in heavy
    drinkers (Majchrowicz and Mendelson, 1971).

    Toxicity resulting from MeOH consumption is extensively
    documented in both humans and animals and has been
    attributed to its metabolite, FA (Benton and Calhoun, 1952;
    Roe, 1946, 1955; Wood, 1912; Wood and Buller, 1904).

    The rate of formate oxidation and elimination is dependent on
    adequate levels of hepatic folic acid, particularly hepatic
    tetrahydrofolate (THF)
    (Johlin et al., 1987; Tephly and McMartin, 1974).

    Significantly higher formate levels were obtained when
    folate-deficient animals were exposed to MeOH as compared
    with folate-sufficient animals (Lee et al., 1994;
    McMartin et al., 1975; Noker et al., 1980).

    To understand ethanol’s toxicity, one must consider FA
    produced from MeOH, and its elimination mediated by folic acid.

    We postulate that in the chronically drinking patient,
    we will find higher levels of FA than in the nondrinking population,
    and that formate is neurotoxic.

    We also hypothesize that treatment with folic acid, which is a
    critical factor in the catabolism of FA, can prevent or
    diminish FA neurotoxicity. [ more at above URL ]

  3. 3 lwtc247 March 13, 2008 at 4:40 am

    @ rightnote
    Thank you for the link although it saddens me that citizens have to do such things which the state should do on our behalf. State conflicts of intrests? you bet!

    @ Rich Murray
    Thank you for the information. The aspartame case shows the power that these “food” (i.e. poison) companies have, whereby the serious concerns over their use comes in the form of empirical data as well as scientific data but still these product are not banned from food – even as a precautionary measure. The same is occuring for GM foods. It is scandalous.

    What can we do? Lobby our elected representitive via short letter and boycott the offending products. We owe it to the future generations if not to ourselves.

    Cheers.

  4. 4 John E. Garst, Ph.D. (Medicinal Chemistry, Pharmacology, and Toxicology) March 13, 2008 at 5:32 pm

    Sorry, but this is pure garbage. There is no conspiracy theory here and the sweet misery website has really got this wrong. Every aspartame experiment to date regardless of its results is fatally flawed. This is especially true though for those who report deleterious effects, because these effects arise soley because of the fundamental and fatal flaw. However, this design error also affects the original Searle experiments and the 2006 and 2007 Soffritti et al experiments reporting leukemia, lymphoma, and mammary tumors from aspartame too. The error itself will cause these types of tumors. Details of the critical and fatal control flaw and two experimental flaws in the Soffritti experiment all will be made known to the scientific community later this month. Reaction to those who know is profound–all these experiments are wrong!. Suffice it to say, if the Searle studies were done incorrectly, the Bressler report which is used to suggest problems with aspartame is invalid too. But then again the entire argument against aspartame, which is based on these flawed experiments, is null and void. “Aspartame is perfectly safe used as directed in healthy people.”

    John E. Garst, Ph.D. (Medicinal Chemistry, Pharmacology, and Toxicology)

    • 5 Ryan July 31, 2009 at 5:50 pm

      Tell that to my father! Who drank it everyday and developed MS or Michael J Fox the spokesperson for Diet Pepsi who is shaking from Parkinson’s. Sorry Mr.Phd, but aspartame is a Neurotoxin and if you keep drinking it you will never see the light! Go ahead and drink up that fluoride that is being put in your water supply buddy and keep reading from the books that they give ya! Another MD disagrees with you!
      http://www.russellblaylockmd.com/

      • 6 caasdcasdgwrb May 22, 2012 at 3:56 pm

        No you’re right. Your father and Michael J Fox is testiment enough and can be held to be statistically valid.

        No. You’re a tool. Get some perspective and common sense and don’t draw on conclusions based on minimal empirical evidence. You’re worse than a bloody Christian.

      • 7 lwtc247 May 22, 2012 at 5:47 pm

        My, what a foul mouth.
        Freshen it up or clear off.
        Capiche?

  5. 8 lwtc247 March 14, 2008 at 9:03 am

    Thank you Dr. Garst for your comment and contribution to the debate.

    The documentary “Sweet Misery” makes a number of specific claims. E.g. by Russell L. Blaylock, M.D. Board-Certified Neurosurgeon who says [5:04 timeline] “we know that the aspartame, because it is a poison that affects protein synthesis, because it affects the halo (or the how the) synapse operates in the brain and because it affects DNA, can affect numerous organs”

    A list dated April 20m 1995 purporting to be a list of symptoms submitted to the FDA, entitled “DEPARTMENT OF HEALTH AND HUMAN SERVICES. SYMPTONS attributed to ASPARTAME in complaint submitted to the FDA” which details reports symptoms, 19.0% of complains or 1,847 people report Headache, followed by 7.5% dizziness / poor equilibrium, then 6.7% a change in mood, Vomiting or nausea at 6.6%, abdominal pain and cramps 4.7%, Change in vision 3.7%, Diarrhea 3.4%, Seizures and convulsions 3.0%, Memory loss 2.6%, fatigue and weakness, 2.5%, other neurological 2.4%. These statistics would have been gathered by a wide range of doctors across the United States to which they have accepted by their discretion (by passing on these statistics) as being associated specifically with aspartame

    The conspiracy is that the chemical was passed without proper scrutiny, and is given labelling which deliberately disguises its presence, e.g. as mentioned earlier use of the words “contains a source of phenylalanine” and in other e.g. Asian countries “contains permitted flavourings” when of course these countries have poorly developed consumer testing facilities and rely on the US FDA rulings as to whether many compounds can be used as food additives. You yourself add credence to that accusation of conspiracy by mentioning further tests after more than 20 years are turning up possible negative consequences regarding the use of aspartame. If the chemical was tested properly and for a full span of acquired diseases and conditions, then further tests would be unnecessary and show no adverse affects.

    Dr Ralph S. Walton, Psychiatrist, also says that “when you take in a lot of aspartame in conjunction with carbohydrates, you decrease the availability of L-tryptophan, the building block of serotonin”

    The conspiracy also involved the political interference particularly in regards to Mr. Donald Rumsfeld (a proven liar and war criminal) as well as actions by Ronald Regan, both of which concern conflicts of interest, which are also mentioned in the documentary but gains no mention by yourself.

    From what you say, there is an indication that you are a part of the team analysing the Soffritti experiment as you display inside information as to the flaw they contain, but actually you are missing the point. The burden is on the drug and additive manufactures to prove it is safe, not to intensely search any, and according to you ALL, studies for the slightest flaw that says it is unsafe. One can draw parallels to HRT and Thalidomide which obviously did were not tested properly.

    It is also incumbent on researchers involved in research of this million dollar generator to reveal their source of funding. As such I ask you to reveal your source of funding in relation to all your work on aspartame.

    If you could also address some of the other claims made in “Sweet Misery” e.g. by John W Olney M.D., Jim Bowen, M.D. emphasis Biochemistry, H.J. Roberts, M.D. Board-Certified Internist, Dr Ralph S. Walton, Psychiatrist, a man who is denied promised funding to conduct double blind tests, amongst others, it would be most helpful

    Thank you.

  6. 9 lwtc247 March 14, 2008 at 9:10 am

    Sorry, I forgot to mention:

    If there is an error in Searles tests which then results in the nullification of the concusions to tests negative to the safety of aspartame, then aspartame should never have been approved in the first place (upon a flawed Searle preliminary study). That’s alone is grounds of aspartames total withdrawl from ALL products worldwide. It’s an open and shut case.

    Regards…
    lwtc247.

  7. 11 lwtc247 March 14, 2008 at 9:14 am

    I also forgot to ask about your statement: “Aspartame is perfectly safe used as directed in healthy people.”

    To make that claim, you need to define its perscription and also what “healthy” is. You also should address the fact that therefore warnings should appear on consumer products saying words to the effect of “do not exceed the recommended dosage, do not consume if you are unhealthy”

    I see no such warnings on any product. I think the reason is clear. Aspartames manufactures (if still in patent) and the manufacturers that lace their products with it would rather not do anything that could damage their sales.

    That is a conspiracy, and it is amoral.

  8. 12 Donna June 7, 2008 at 5:32 pm

    Excellent post and resources!

    Can I add something about aspartame?

    Aspartame (or APM) (pronounced /ˈæspɚteɪm/ or /əˈspɑrteɪm/) is the name for an artificial, non-saccharide sweetener, aspartyl-phenylalanine-1-methyl ester; i.e., a methyl ester of the dipeptide of the amino acids aspartic acid and phenylalanine.

    This sweetener is marketed under a number of trademark names, including Tropicana Slim, Equal, NutraSweet, and Canderel, and is an ingredient of approximately 6,000 consumer foods and beverages sold worldwide. It is commonly used in diet soft drinks, and is often provided as a table condiment.

    It is also used in some brands of chewable vitamin supplements and common in many sugar-free chewing gums. However, aspartame is not always suitable for baking because it often breaks down when heated and loses much of its sweetness. In the European Union, it is also known under the E number (additive code) E951. Aspartame is also one of the sugar substitutes used by people with diabetes.

    Aspartame is a subject of a public controversy due to possible health risks, and has consequently lost market share in recent years to sucralose (Splenda).

    Aspartame is an artificial sweetener. It is 180 times as sweet as sugar in typical concentrations, without the high energy value of sugar. While aspartame, like other peptides, has a caloric value of 4 kilocalories (17 kilojoules) per gram, the quantity of aspartame needed to produce a sweet taste is so small that its caloric contribution is negligible, which makes it a popular sweetener for those trying to avoid calories from sugar. The taste of aspartame is not identical to that of sugar: the sweetness of aspartame has a slower onset and longer duration than that of sugar, and some consumers find it unappealing. Blends of aspartame with acesulfame potassium—usually listed in ingredients as acesulfame K—are alleged to taste more like sugar, and to be sweeter than either substitute used alone.

    Like many other peptides, aspartame may hydrolyze (break down) into its constituent amino acids under conditions of elevated temperature or high pH. This makes aspartame undesirable as a baking sweetener, and prone to degradation in products hosting a high-pH, as required for a long shelf life. The stability of aspartame under heating can be improved to some extent by encasing it in fats or in maltodextrin. The stability when dissolved in water depends markedly on pH. At room temperature, it is most stable at pH 4.3, where its half-life is nearly 300 days. At pH 7, however, its half-life is only a few days. Most soft-drinks have a pH between 3 and 5, where aspartame is reasonably stable. In products that may require a longer shelf life, such as syrups for fountain beverages, aspartame is sometimes blended with a more stable sweetener, such as saccharin.

    In products such as powdered beverages, the amine in aspartame can undergo a Maillard reaction with the aldehyde groups present in certain aroma compounds. The ensuing loss of both flavor and sweetness can be prevented by protecting the aldehyde as an acetal.

  9. 13 lwtc247 June 8, 2008 at 10:52 am

    Thank you Donna for that scientific addition. Aspartame is a cumulative poison. No doubt. Foods simply don’t need it. Either do people.

    Junk it and spread the word.

  10. 14 caasdcasdgwrb May 22, 2012 at 3:53 pm

    Quote;

    ”Food products are sometimes say on their labels ”contains a source of phenylalanine“. They say that becasue they know people don’t want to consume aspartame as people are increasingly aware of its adverse effects”

    Google Phenylketonuria you numpty!

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